200L double-layer jacketed glass reactor

1、 Product Overview

200L double-layer jacketed glass reactor is a core reaction equipment suitable for pilot scale amplification and small-scale industrial production, which meets the needs of laboratory precision experiments and mass production operations. It is widely used in various fields such as fine chemicals, biopharmaceuticals, new material synthesis, food additives, environmental research, etc. The equipment adopts a double-layer high borosilicate glass integrated structure, relying on the principles of interlayer temperature control cycle, closed vacuum reaction, and uniform stirring reaction. It can efficiently complete various process operations such as stirring, synthesis, distillation, reflux, concentration, extraction, purification, crystallization, etc. It is the preferred equipment for scientific research conversion, batch trial production, and process optimization. Compared to small reaction vessels, the 200L high-capacity model has higher heat transfer efficiency, larger material handling capacity, and stronger operational stability. It perfectly connects laboratory small-scale testing with industrial mass production, effectively solving problems such as data deviation and insufficient production capacity during process amplification.

2、 Working principle

The equipment adopts a double-layer hollow glass structure, with an inner cavity used to hold reaction materials and independently complete various chemical reactions; The double-layer sandwich chamber can be filled with thermal oil, cooling water, antifreeze and other cold and hot circulation media, and is equipped with temperature control equipment such as high and low temperature integrated machines and chillers to achieve precise constant temperature heating, cooling and temperature control operations within the range of -120 ℃ to 300 ℃. The equipment as a whole can achieve closed vacuum operation, equipped with a variable frequency speed control stirring system, allowing materials to fully react in a stable environment of constant temperature, constant speed, and vacuum oxygen free, effectively avoiding material oxidation and volatilization loss, improving reaction conversion rate and product purity. At the same time, it can be matched with a condensation recovery device to achieve solvent recycling and reduce production costs.

3、 Core material advantages

The whole kettle body is made of refined G3.3 high borosilicate heat-resistant glass, with low glass expansion coefficient and excellent transparency, possessing super strong physical stability and chemical corrosion resistance. Can withstand corrosion from various corrosive materials such as strong acids, strong alkalis, and organic solvents, does not undergo chemical reactions with reaction materials, does not precipitate impurities, and ensures material purity; At the same time, it has excellent heat shock resistance, can withstand rapid temperature rise and fall conditions, and is not easy to explode or deform. The sealing components and mixing components of the equipment are made of high-purity polytetrafluoroethylene material, which is resistant to high temperature, corrosion, and has strong sealing performance, eliminating material leakage and air leakage problems, and is suitable for various high cleanliness and high anti-corrosion process scenarios.

4、 Product structure configuration

1. Visualized kettle structure: 200L standard effective volume, sufficient interlayer heat transfer capacity, and intuitive observation of material reaction status, color changes, and crystallization process throughout the process, facilitating real-time adjustment of process parameters and precise control of reaction progress. A multifunctional interface is reserved at the top of the kettle body, which can adapt to multi-channel operations such as feeding, temperature measurement, vacuum, reflux, and pressure relief, and support diversified process combinations.

2. Variable frequency mixing system: equipped with a low-speed booster explosion-proof motor, the mixing speed is infinitely adjustable from 0-280rpm, running smoothly, with sufficient torque and low noise, suitable for mixing high viscosity and large batches of materials. Paired with customized PTFE stirring blades, it has a wide mixing range and high mixing uniformity, eliminating problems such as material precipitation and uneven reaction, and meeting the mixing and reaction needs of different materials.

3. High sealing vacuum system: adopting precision mechanical seal design, the whole machine has excellent sealing performance and can maintain a high vacuum working environment. It is suitable for processes such as negative pressure distillation, vacuum defoaming, and anaerobic synthesis, effectively reducing the boiling point of materials, avoiding high-temperature material decomposition, and improving process safety and product quality.

4. Safety protection structure: equipped with dedicated pressure relief valves, anti explosion protection design, automatic pressure relief for overpressure, eliminating the risk of pressure overload; The bottom is equipped with a large-diameter discharge valve, which is sealed with PTFE and has no residue. The discharge is smooth and easy to clean, supporting complete unloading of materials and reducing material loss. The entire machine frame is made of thickened stainless steel material, which provides stable load-bearing, rust and corrosion resistance, and is suitable for long-term continuous operation.

5、 Core features of the product

1. Precise temperature control and efficient heat transfer: The double-layer sandwich design with a large heat transfer area ensures even circulation of cold and hot media, fast temperature rise and fall speed, small temperature error, and stable temperature throughout the entire area, suitable for harsh high and low temperature cycle reaction processes.

2. One machine is versatile and has wide process compatibility: it can independently complete various processes such as synthesis, distillation, reflux, concentration, extraction, crystallization, and defoaming, and is suitable for the vast majority of chemical, pharmaceutical, and new material reaction scenarios. The equipment has strong versatility and significantly reduces equipment investment costs.

3. Clean and anti-corrosion, high quality of finished products: Glass and PTFE materials have no adsorption, no pollution, acid and alkali corrosion resistance, suitable for the production of high-purity pharmaceutical intermediates, fine chemicals and other high-end materials, meeting GMP clean production requirements.

4. Easy to operate and maintain: visual operation, variable frequency speed regulation, intelligent temperature control, simple and intuitive parameter adjustment; Detachable structural design, convenient equipment cleaning, maintenance, and accessory replacement, no hygiene dead corners, suitable for frequent material changing operations.

5. Stable operation and high safety: The explosion-proof motor, pressure relief protection, and sealed leak proof multiple safety designs support 24-hour continuous stable operation with low failure rate, meeting the high-intensity operation requirements of pilot and small-scale mass production.

6、 Core technical parameters

7、 Applicable industry scenarios

1. Biopharmaceuticals: synthesis of pharmaceutical intermediates, purification of raw materials, reaction of biologics, concentration and crystallization of drug solutions;

2. Fine chemicals: synthesis of additives, dyes, fragrances, surfactants, emulsification reactions, solvent recovery;

3. New materials research: synthesis and process development of polymer materials, nanomaterials, and lithium battery materials;

4. Food and daily chemicals: synthesis and purification of food additives, essence and fragrances, and cosmetics raw materials;

5. Environmental research: synthesis of wastewater treatment agents, extraction and separation of pollutants, and development of environmentally friendly materials;

6. University research: pilot experiments in university laboratories, process scale-up verification, and teaching and practical training.

8、 Supporting equipment

It can be paired with high and low temperature integrated machines, low-temperature coolant circulation pumps, circulating water vacuum pumps, diaphragm vacuum pumps, condensation recovery devices, feeding systems, intelligent temperature control systems, and other equipment to form a complete automated reaction production line, achieving closed-loop operations throughout the entire process and improving production efficiency and process stability.